Monitoring clinical trials interim data should be publicly available

How should individual participant data (IPD) from publicly funded clinical trials be shared?

BACKGROUND Individual participant data (IPD) from completed clinical trials should be responsibly shared to support efficient clinical research, generate new knowledge and bring benefit to patients. The Medical Research Council (MRC) Hubs for Trials Methodology Research (HTMR) has developed guidance to facilitate the sharing of IPD from publicly funded clinical trials. METHODS Development of ...

North American regulatory agencies can and should make clinical trial data publicly available.

Should uterus transplants be publicly funded?

Since 2000, 11 human uterine transplantation procedures (UTx) have been performed across Europe and Asia. Five of these have, to date, resulted in pregnancy and four live births have now been recorded. The most significant obstacles to the availability of UTx are presently scientific and technical, relating to the safety and efficacy of the procedure itself. However, if and when such obstacles ...

Issues in data monitoring and interim analysis of trials.

OBJECTIVES To address issues about data monitoring committees (DMCs) for randomised controlled trials (RCTs). DATA SOURCES Electronic databases. Handsearching of selected books. Personal contacts with experts in the field. REVIEW METHODS Systematic literature reviews of DMCs and small group processes in decision-making; sample surveys of: reports of RCTs, recently completed and ongoing RCTs...

Inferring App Demand from Publicly Available Data

With an abundance of products available online, many online retailers provide sales rankings to make it easier for consumers to find the best-selling products. Successfully implementing product rankings online was done a decade ago by Amazon, and more recently by Apple’s App Store. However, neither market provides actual download data, a very useful statistic for both practitioners and research...